Doxorubicin PowerPoint Template

Doxorubicin PPT Template: Animated Medical PowerPoint

• Are you trying to explain Doxorubicin's complex mechanisms of action? Engage your audience with the Doxorubicin PPT template, an animated medical PowerPoint template designed by RxSlides medical professionals.
• Imagine impressive animations illustrating Doxorubicin's journey through the body, bringing the drug mechanism to life.
• You also ensure scientific accuracy, which is guaranteed by the expertise of RxSlides medical professionals.
• You can explore other drugs PowerPoint templates on RxSlides.

Doxorubicin PPT Template Table of Contents

• Cover slides having vial and pegylated liposomal doxorubicin illustrations.

Medical overview

• This section provides various medical slides exploring essential breast cancer, leukemia and lymphoma topics.

Breast cancer overview

• We initially start with illustrated breast anatomy showing axillary lymph node duct areola nipples and internal lymph node lobule adipose tissue.
• Then, the breast cancer pathology is explained with illustrations demonstrating that estrogen receptors, progesterone receptors and HER2 neu receptors are overexpressed and breast cancer can be metastatic to bones, lungs and liver.
• You can get deeper explanations and more illustrations about breast cancer with RxSlides animated PowerPoint on breast cancer.

Leukemia overview

• Leukemia is also illustrated with visuals of blood cell generation.
• To clarify the concept, we provide a comparative illustration between normal blood and blood with leukemia.
• You can get more graphs and visuals about blood cell generation and transformation in our leukemia PPT template.

Lymphoma overview

• This part shows the illustrated lymphatic system anatomy, including lymph nodes, lymph vessels, bone marrow, tonsils, thymus gland and spleen.
• Another illustration shows lymph node anatomy, including the primary lymphoid follicle, paracortical area, efferent lymph vessel, secondary lymphoid follicle, germinal center and afferent lymph vessel.
• You can also notice comparison infographics concerning the origin of cancer, either primary or secondary.
• You can notice with this introduction that complex medical concepts become readily apparent through the power of animation, driving a deeper understanding of critical topics in the presentation.

What is doxorubicin

• Doxorubicin's chemical structure is illustrated; functional groups are the amine group in the sugar moiety and the primary hydroxyl group in the aliphatic chain of ring B.
• According to the National Institute of Health NIH, Doxorubicin is classified as a cytotoxic anthracycline antibiotic.
• This section in the Doxorubicin PPT template provides illustrations for the Doxorubicin dosage of different concentrations, a large vial and a small vial with labels.
• Pfizer markets this drug under the brand name of Adriamycin.
• Adriamycin is available in vials containing 10 mg/5 ml and 50 mg/25 ml of doxorubicin hydrochloride.

Pharmacokinetics of doxorubicin

• Medical charts and graphs illustrate the steady-state distribution volume and extensive drug uptake into tissues.
• Illustrations show that Doxorubicin is excreted in the milk of one lactating patient.
• Medical graphs explain that plasma clearance and slow elimination from tissues are reflected by a terminal half-life of 20 to 48 hours.
• In this Doxorubicin PPT template, we provide a pegylated liposomal doxorubicin structure illustrating the liposomal layer, encapsulated Doxorubicin and coating.
• Liposomal Doxorubicin and pegylated liposomal Doxorubicin are less toxic, have better cardiac safety and have fewer side effects compared with conventional anthracyclines.
• Liposomal anthracyclines are a favorable choice for elderly patients, patients with risk factors for cardiac disease and patients who have previously used anthracyclines.

Mechanism of action of doxorubicin

• Initially, we start by explaining the target enzyme, Type II topoisomerases. Animations show that the topoisomerases cut both strands of the DNA helix simultaneously to manage DNA tangles and supercoils in animals; topoisomerase II is a chemotherapy target.
• Doxorubicin exerts its anticancer effect through intercalation and topoisomerase II inhibition.
• Intercalation: The animation shows that the drug interacts with DNA by intercalation and inhibition of macromolecular biosynthesis, which inhibits the progression of the enzyme topoisomerase II, preventing the relaxation of supercoils in DNA for transcription.
• Topoisomerase II inhibitor: Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the re-ligation portion of the ligation-re-ligation reaction that topoisomerase II catalyzes.
• In this part of the Doxorubicin PPT template, you will notice visually animated illustrations, made in detail, explaining the mechanism of action of Doxorubicin, from receptor binding to downstream effects.

Indications of doxorubicin

• Doxorubicin is indicated for bone sarcomas and breast, ovary, bladder and thyroid cancers.
• It also treats acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin lymphoma and small-cell lung cancer.
• The liposomal formulation of Doxorubicin has FDA approval for the treatment of ovarian cancer in patients who have failed platinum-based chemotherapy, AIDS-related Kaposi sarcoma and multiple myeloma.

Side effects of doxorubicin

• Serious side effects include cardiotoxicity, arrhythmia, life-threatening cardiomyopathy, CHF, pericarditis, myocarditis, secondary leukemia and myelodysplastic syndrome.
• The drug also causes common side effects such as hair loss, nausea, vomiting, diarrhea, fatigue and a low WBC count.
• We added visuals in the Doxorubicin PPT template to help memorize these side effects.

Clinical studies template

• In this section of the Doxorubicin PowerPoint template, you will notice that we have inserted many medical infographics, graphs, charts and illustrations to visualize different clinical trial steps.
• You can use the mentioned assets to explain clinical trials' importance, methods, phases, results and conclusions.

Contraindications of doxorubicin

• The drug is contraindicated in cases of sensitivity to the drug or one of its components: trastuzumab use within seven months; IM use; SC use; first trimester of pregnancy.

Black-box warnings

• According to Medscape, the drug has a black box warning, as it may cause cardiotoxicity, extravasation, myelodysplastic syndromes and myelosuppression. Myocardial damage, including acute left ventricular failure, can occur; increased risk is associated with a higher cumulative dose.

Drug interactions with Doxorubicin

• Medical infographics in the Doxorubicin PPT template explain that Doxorubicin is contraindicated with Adenovirus live vaccine, Typhoid live vaccine, Varicella live vaccine, yellow fever vaccine, Cholera live vaccine, Dengue live vaccine, Influenza live vaccine, MMR live vaccine, Rotavirus live vaccine and Smallpox live vaccine.
• The drug is contraindicated with BCG live intravenous; concurrent use may increase the risk of disseminated BCG infection.
• It is also contraindicated with Talimogene laherparepvec, as this combination may increase the risk of disseminated herpetic infection.
• Medical infographics explain that these interactions may cause immunosuppressive effects.

RxSlides visuals for doxorubicin PowerPoint template

• You can notice that RxSlides provides you with a set of PowerPoint icons and illustrations related to Doxorubicin that will help you customize the content of this 100% editable presentation according to your content and audience interest.
• This Doxorubicin PPT template provides you with customizable and engaging medical infographics; you can easily tailor the Doxorubicin presentation to your specific needs to keep your audience informed and engaged.